The BioPersist platform contains an operon that allows the bacteria to maintain its metabolic function in an inflamed environment, hence increasing its chance for therapeutic success in the gut.

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In our intestines, microbes must compete for energy resources to survive. However, bacteria with our genetic modification can use a different energy source that is produced in the intestines during inflammation. Unlike typical probiotics and live biotherapeutics, beneficial bacteria containing our BioPersist platform can persist during inflammation. Successful persistence allows for these bacteria to compete with harmful pathogens and provide their natural healing properties to help restore the gut to a healthy state.

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Using this platform of genes, we can take a personalized approach to medicine in which we insert these genes into a bacteria that is suitable for the individual’s microbiome. We also can expand the use of these modifications to be added into bacteria that are tailored for non-human hosts such as horses, pigs, and cats/dogs.