Engineering Resilience for Optimal Gut Health
BioPersist™
Technology
BioPersist™ enhances beneficial bacteria with specific genes that enable them to thrive and function in an inflamed gut. By allowing beneficial bacteria to persist in an inflamed environment, they can compete with harmful bacteria and provide their natural anti-inflammatory benefits that promote mucosal healing. Several strains of BioPersist™ can be developed using our genetic platform, which allows for personalized microbial treatments across various hosts.
How Does it Work?
BioPersist™ refers to any beneficial bacteria that has been genetically engineered to include our patented genetic platform. This platform of genes contains an operon that allows the bacteria to maintain its metabolic function in an inflamed environment, hence increasing its chance for therapeutic success in the gut.
In our intestines, microbes must compete for energy resources to survive. However, bacteria with our genetic modification can use a different energy source that is produced in the intestines during inflammation. The small addition of these genes into a beneficial bacteria allows it to compete with potentially harmful bacteria and persist during inflammation, where it can provide its natural anti-inflammatory and healing properties to help restore the gut to a healthy state.
Using this platform of genes, we can take a personalized approach to medicine in which we can insert these genes into a bacteria that is suitable for the individual’s microbiome. We also can expand the use of these modifications to be added into bacteria that are tailored for non-human hosts such as horses, pigs, and cats/dogs.